Carson City District Court Judge James Russell said Friday that the measure was too broad and general in nature to be put before voters in November.
Backers of the proposal say they plan to appeal to the Nevada Supreme Court.
The proposed initiative would amend the state Constitution by defining a person and extending due process rights to "everyone possessing a human genome" from the beginning of biological development through end of life.
Three plaintiffs represented by lawyers for Planned Parenthood and the American Civil Liberties Union challenged the proposal as too vague.
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