The Wolf Pack standouts poured in 32 and 31 points respectively, both career highs. Burton buried 14-of-20 field goal tries while Huff was 11-of-19 from the floor, including 6-of-10 from 3-point land. Huff's previous scoring high was 16.
Nevada shot a solid 37-of-76 (48.7 percent) from the floor, just a bit better than Fresno State's 30-of-74 (40.5 percent) effort.
The Wolf Pack trailed 76-74 at the end of regulation but got a layup with eight seconds to go from Burton to tie the game and force overtime. In the extra session, Nevada faced an 82-80 deficit, but Huff dropped in a layup with less than a second remaining to force the second overtime.
That's when Nevada took firm control, posting the first nine points of double overtime en route to earning the key conference win. The two teams have played three overtime games in their last four meetings and the road team has won on each occasion extra time was needed.
Nevada also got 15 points from Jerry Evans Jr. AJ West chipped in just five points for the Pack but he grabbed 13 rebounds and recorded eight blocks.
Fresno State had already played three overtime games this winter and won the previous three. The Bulldogs offense was paced by the 20 points of Tyler Johnson and 18 points of Marvelle Harris.
Nevada now sits 10-9 overall and 5-1 in MWC tilts. The Pack is in action again Saturday at Wyoming at 1 p.m.
Fresno State falls to 8-12 overall and 1-6 in the MWC.