The loss, at Thomas & Mack Arena in Las Vegas, was Nevada's third against Wyoming this season and sends the Wolf Pack home for the offseason with a 12-19 record.
Nevada took a 36-32 lead into the locker room at the intermission but an ice cold spell out of the break sealed the Pack's fate. Wyoming started the second half on a 19-4 run, a spurt that lasted more than six minutes. Nevada did not record its first field goal of the second half until the 12:23 mark.
Wyoming shot a much higher percentage form the field, 57.4 percent (27-47) compared to Nevada's 47.5 percent mark (28-59). However, the Cowboys got the foul line 37 times and knocked down 24 of those tries. Conversely Nevada got only 25 tries, making 15.
Deonte Burton poured in 27 points for Nevada, which also got 20 points from Malik Story and 14 points from Marqueze Coleman. The problem for the Wolf Pack was it didn't get much balance beyond that. The trio combined for 61 points, but the rest of the roster managed just 20.
Four Wyoming players hit for double digits in the scoring column. Larry Nance Jr. made 9 of 10 field-goal attempts and led the Cowboys with 19 points, while Leonard Washington chipped in 18 points. Derrious Gilmore and Josh Adams added 17 and 10 points respectively.
Wyoming put up 53 second-half points to help its cause. That is the most points by a Cowboys team in a half since 2005 and the third most points ever in a MWC tournament tilt.
Wyoming (19-12) improved to 16-1 on the season when it eclipsed the 60-point mark.
Nevada was saddled with its second losing season in three years after a string of nine-straight winning seasons.