McQueen led 21-9 after the first quarter and had pushed its lead to 39-19 by halftime.
Galena did score 22 and 24 points in the third and fourth quarters respectively but never really threatened McQueen.
CJ Grigg scored 20 points to lead McQueen on the offensive end. He got some help as his Lancers teammates Joe Saarem and Lukas Engstrom chipped in 15 and 13 points.
Zane Copenhaver and Kyle Stewart paced Galena in a losing effort with 20 and 13 points.
Galena was playing without 6-foot 3-inch starting senior post Nate Hosmer and it proved costly.
"It was an inside game. We pounded the ball inside," McQueen coach John Franklin said. "Galena was without its best player so that was a tough blow to them, but coach (Tom) Maurer has had them in the playoffs for 15 straight years. So you know they'll always play hard."
McQueen will meet Manogue at 5 p.m. in a regional semifinal at Carson High Thursday. Manogue may have played its best game of the year two weeks ago in a romp over McQueen. Don't expect the Lancers to forget.
"That first playoff game is always important, but they're all important," Franklin said. "We're doing everything we can to try and compete for a championship. Winning the first game is good, but it's about winning them all, starting now."
Douglas 69, Reno 46
•After getting upset at home in the first-round of the playoffs last year, the Douglas Tigers were determined not to let it happen again. The Sierra League runners-up made sure of it Tuesday night, drilling High Desert League No. 3 seed Reno, 69-46, in a first-round Northern 4A regional playoff game.
Douglas used second-half runs of 14-3 and 16-2 to put away the visiting Huskies, who had not been eliminated in the first round of the playoffs in the last seven years.
The game was deadlocked at 17-17 after one quarter but Douglas held a 35-29 edge at the intermission.
Reno got as close as 35-33 early in the third quarter, but that's as good as it got for the visitors as Douglas responded with its 14-3 outburst.
Austin Neddenriep poured in a game-high 22 points for Douglas (22-4) on the strength of six 3-pointers.
"I'm glad it (the outside shooting) came out tonight," Douglas coach Corey Thacker said. "It really helped us extend the lead in some key spots.
Douglas (22-4) will meet Hug at 7 p.m. Thursday at Carson High in a regional semifinal.